Compound Detail
CHEMBL32573
TRAMAZOLINE 🧪 Phase II
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🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL32573 |
| Name | TRAMAZOLINE |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | QQJLHRRUATVHED-UHFFFAOYSA-N |
2
Targets
3
Activities
2
Assay Types
0
PK Parameters
8
Publications
3
Known Names
1
Indications
Molecular Properties
215.3
MW (Da)
1.94
ALogP
3
HBA
2
HBD
36.4
PSA (Ų)
0.75
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Achiral |
Indications
Nasal Obstruction
ATC Classification
R01AA09
tramazoline
Level 1: RESPIRATORY SYSTEM
Level 2: NASAL PREPARATIONS
Activity Summary
IC50 2 meas. best 7.8
Ki 1 meas. best 8.38
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Adrenergic receptor alpha-2 CHEMBL2093864 | Ki | 8.38 | 8.38 | 4.2 | 1 |
| Adrenergic receptor alpha-2 CHEMBL2093864 | IC50 | 7.8 | 7.8 | 16.0 | 1 |
| Adrenergic receptor alpha-1 CHEMBL1907610 | IC50 | 5.96 | 5.96 | 1100.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Adrenergic receptor alpha-2 | Ki | = | 4.2 | nM | 8.38 | Displacement of [3H]clonidine from Alpha-2 adrenergic receptor of rat brain memb... | 6296387 |
| Adrenergic receptor alpha-2 | IC50 | = | 16.0 | nM | 7.8 | Binding affinity against Alpha-2 adrenergic receptor is the ability to inhibit t... | 6142954 |
| Adrenergic receptor alpha-1 | IC50 | = | 1100.0 | nM | 5.96 | 50% inhibition of specific [3H]prazosin binding (0.4 nM) to Alpha-2 adrenergic r... | 6142954 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 6142954 | 10.1021/jm00370a011 | Oryctolagus cuniculus | 2 |
| 6105218 | 10.1021/jm00182a015 | Rattus norvegicus | 2 |
| 6264080 | 10.1021/jm00137a006 | Adrenergic receptor alpha | 2 |
| 6142954 | 10.1021/jm00370a011 | No relevant target | 1 |
| 6142954 | 10.1021/jm00370a011 | Adrenergic receptor alpha-1 | 1 |
| 6142954 | 10.1021/jm00370a011 | Adrenergic receptor alpha-2 | 1 |
| 6296387 | 10.1021/jm00354a001 | Adrenergic receptor alpha-2 | 1 |
| 6264080 | 10.1021/jm00137a006 | No relevant target | 1 |
Data from ChEMBL 36 via Core Engine