Compound Detail
CHEMBL327340
TETRAMETHYLLUTEOLIN Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL327340 |
| Name | TETRAMETHYLLUTEOLIN |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | CLXVBVLQKLQNRQ-UHFFFAOYSA-N |
1
Targets
3
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
342.4
MW (Da)
3.49
ALogP
6
HBA
0
HBD
67.1
PSA (Ų)
0.71
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 5.5
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| RAW264.7 CHEMBL612557 | IC50 | 5.5 | 4.7067 | 3130.0 | 3 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| RAW264.7 | IC50 | = | 3130.0 | nM | 5.5 | Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-... | 28408221 |
| RAW264.7 | IC50 | = | 32500.0 | nM | 4.49 | Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-... | 28408221 |
| RAW264.7 | IC50 | = | 73940.0 | nM | 4.13 | Cytotoxicity against mouse RAW264.7 cells by MTT assay | 28408221 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 28408221 | 10.1016/j.bmcl.2017.03.057 | RAW264.7 | 5 |
| 21493073 | 10.1016/j.bmc.2011.03.040 | 3T3-L1 | 4 |
| 33038547 | 10.1016/j.bmcl.2020.127606 | Unchecked | 3 |
| 11170636 | 10.1021/jm0004190 | Staphylococcus aureus | 1 |
| 21907578 | 10.1016/j.bmcl.2011.08.077 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine