Assay Detail
Functional
CHEMBL4029930
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Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated PGE2 production by ELISA
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | RAW264.7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Identification and structure activity relationship of novel flavone derivatives that inhibit the production of nitric oxide and PGE2 in LPS-induced RAW 264.7 cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.47 | 6.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL521 | IBUPROFEN | 4.0 | 1 | 6.41 |
| CHEMBL222556 | — | — | 1 | 6.00 |
| CHEMBL151 | LUTEOLIN | 2.0 | 1 | 5.54 |
| CHEMBL327340 | TETRAMETHYLLUTEOLIN | — | 1 | 5.50 |
| CHEMBL327209 | — | — | 1 | 5.42 |
| CHEMBL91153 | 3',4'-DIMETHOXYFLAVONE | — | 1 | 5.19 |
| CHEMBL7162 | NS-398 | — | 1 | 5.17 |
| CHEMBL275391 | CHRYSIN DIMETHYL ETHER | — | 1 | 5.13 |
| CHEMBL1278226 | — | — | 1 | 4.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL521 | IBUPROFEN | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL222556 | — | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL151 | LUTEOLIN | IC50 | = | 2870.0 | nM | 5.54 |
| CHEMBL327340 | TETRAMETHYLLUTEOLIN | IC50 | = | 3130.0 | nM | 5.50 |
| CHEMBL327209 | — | IC50 | = | 3770.0 | nM | 5.42 |
| CHEMBL91153 | 3',4'-DIMETHOXYFLAVONE | IC50 | = | 6460.0 | nM | 5.19 |
| CHEMBL7162 | NS-398 | IC50 | = | 6740.0 | nM | 5.17 |
| CHEMBL275391 | CHRYSIN DIMETHYL ETHER | IC50 | = | 7430.0 | nM | 5.13 |
| CHEMBL1278226 | — | IC50 | = | 14010.0 | nM | 4.85 |