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Compound Detail

CHEMBL3289643

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O=C1c2ccccc2CC1CCN1CCN(c2ccc(Cl)cc2)CC1

Basic Information

ChEMBL ID CHEMBL3289643
Phase Preclinical
Structure Type MOL
InChI Key CPFAMVVFLCOFSK-UHFFFAOYSA-N
3
Targets
6
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names

Molecular Properties

354.9
MW (Da)
3.91
ALogP
3
HBA
0
HBD
23.6
PSA (Ų)
0.83
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C21H23ClN2O
MW 354.88
Aromatic Rings 2
Heavy Atoms 25
NP-Likeness -0.88

Activity Summary

Ki 6 meas. best 7.45

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
D(4) dopamine receptor
CHEMBL3361
Ki 7.45 7.445 35.5 2
D(1A) dopamine receptor
CHEMBL2056
Ki 6.41 6.09 389.1 2
D(3) dopamine receptor
CHEMBL234
Ki 5.34 5.34 4534.0 2

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
24800940 10.1016/j.bmc.2014.04.026 D(1A) dopamine receptor 2
24800940 10.1016/j.bmc.2014.04.026 D(3) dopamine receptor 2
24800940 10.1016/j.bmc.2014.04.026 D(4) dopamine receptor 2
24800940 10.1016/j.bmc.2014.04.026 Unchecked 2
24800940 10.1016/j.bmc.2014.04.026 D(2) dopamine receptor 1
24800940 10.1016/j.bmc.2014.04.026 D(1B) dopamine receptor 1

Data from ChEMBL 36 via Core Engine