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Compound Detail

CHEMBL3289644

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Fc1ccc2c(c1)CC(CCN1CCN(c3ccc(Cl)cc3)CC1)C2

Basic Information

ChEMBL ID CHEMBL3289644
Phase Preclinical
Structure Type MOL
InChI Key XASUAOWUPBWGMW-UHFFFAOYSA-N
4
Targets
4
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names

Molecular Properties

358.9
MW (Da)
4.41
ALogP
2
HBA
0
HBD
6.5
PSA (Ų)
0.80
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C21H24ClFN2
MW 358.89
Aromatic Rings 2
Heavy Atoms 25
NP-Likeness -1.42

Activity Summary

Ki 4 meas. best 7.89

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
D(4) dopamine receptor
CHEMBL3361
Ki 7.89 7.89 13.0 1
D(1A) dopamine receptor
CHEMBL2056
Ki 6.08 6.08 837.0 1
D(2) dopamine receptor
CHEMBL217
Ki 5.85 5.85 1417.0 1
D(3) dopamine receptor
CHEMBL234
Ki 5.56 5.56 2772.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
24800940 10.1016/j.bmc.2014.04.026 Unchecked 2
24800940 10.1016/j.bmc.2014.04.026 D(1A) dopamine receptor 1
24800940 10.1016/j.bmc.2014.04.026 D(2) dopamine receptor 1
24800940 10.1016/j.bmc.2014.04.026 D(3) dopamine receptor 1
24800940 10.1016/j.bmc.2014.04.026 D(4) dopamine receptor 1
24800940 10.1016/j.bmc.2014.04.026 D(1B) dopamine receptor 1

Data from ChEMBL 36 via Core Engine