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Compound Detail

CHEMBL3289655

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Clc1ccc(N2CCCN(CCCc3cc4ccccc4o3)CC2)cc1

Basic Information

ChEMBL ID CHEMBL3289655
Phase Preclinical
Structure Type MOL
InChI Key MKNOKGDTUIIQRL-UHFFFAOYSA-N
5
Targets
5
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names

Molecular Properties

368.9
MW (Da)
5.23
ALogP
3
HBA
0
HBD
19.6
PSA (Ų)
0.61
QED
1
Ro5 Violations
5
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C22H25ClN2O
MW 368.91
Aromatic Rings 3
Heavy Atoms 26
NP-Likeness -1.27

Activity Summary

Ki 5 meas. best 6.73

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
D(4) dopamine receptor
CHEMBL3361
Ki 6.73 6.73 185.0 1
D(1A) dopamine receptor
CHEMBL2056
Ki 6.56 6.56 274.0 1
D(3) dopamine receptor
CHEMBL234
Ki 5.83 5.83 1462.0 1
D(1B) dopamine receptor
CHEMBL1850
Ki 5.82 5.82 1522.0 1
D(2) dopamine receptor
CHEMBL217
Ki 5.6 5.6 2507.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
24800940 10.1016/j.bmc.2014.04.026 Unchecked 2
24800940 10.1016/j.bmc.2014.04.026 D(1A) dopamine receptor 1
24800940 10.1016/j.bmc.2014.04.026 D(2) dopamine receptor 1
24800940 10.1016/j.bmc.2014.04.026 D(3) dopamine receptor 1
24800940 10.1016/j.bmc.2014.04.026 D(4) dopamine receptor 1
24800940 10.1016/j.bmc.2014.04.026 D(1B) dopamine receptor 1

Data from ChEMBL 36 via Core Engine