Compound Detail
CHEMBL33096
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Basic Information
| ChEMBL ID | CHEMBL33096 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | RGAJIKNGJBAVQP-UHFFFAOYSA-N |
2
Targets
4
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
392.5
MW (Da)
5.12
ALogP
5
HBA
0
HBD
43.7
PSA (Ų)
0.62
QED
1
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 8.05
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Translocator protein CHEMBL4552 | IC50 | 8.05 | 8.0467 | 9.0 | 3 |
| Voltage-gated L-type calcium channel CHEMBL2095177 | IC50 | 6.38 | 6.38 | 420.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Translocator protein | IC50 | = | 9.0 | nM | 8.05 | Ability to inhibit [3H]-PK 11195 binding to peripheral-type benzodiazepine recep... | 8709127 |
| Translocator protein | IC50 | = | 9.0 | nM | 8.05 | Displacement of [3H]-PK 11195 from peripheral (mitochondrial) benzodiazepine rec... | 8182701 |
| Translocator protein | IC50 | = | 9.12 | nM | 8.04 | Displacement of [3H]-PK 11195 from rat peripheral (mitochondrial) benzodiazepine... | 7990110 |
| Voltage-gated L-type calcium channel | IC50 | = | 420.0 | nM | 6.38 | Ability to inhibit [3H]nitrendipine binding to the calcium channel receptor(CCR)... | 8709127 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 8709127 | 10.1021/jm960162z | Voltage-gated L-type calcium channel | 1 |
| 8709127 | 10.1021/jm960162z | Translocator protein | 1 |
| 8709127 | 10.1021/jm960162z | Voltage-dependent L-type calcium channel subunit alpha-1C | 1 |
| 8182701 | 10.1021/jm00036a007 | Translocator protein | 1 |
| 7990110 | 10.1021/jm00050a007 | Translocator protein | 1 |
Data from ChEMBL 36 via Core Engine