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Compound Detail

CHEMBL3319231

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N=C(N)NCCCCC(=O)NCC(=O)NC(CC(=O)O)c1cccnc1

Basic Information

ChEMBL ID CHEMBL3319231
Phase Preclinical
Structure Type MOL
InChI Key CQDWPOURVPAZAM-UHFFFAOYSA-N
5
Targets
6
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names

Molecular Properties

364.4
MW (Da)
-0.52
ALogP
5
HBA
6
HBD
170.3
PSA (Ų)
0.17
QED
1
Ro5 Violations
11
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C16H24N6O4
MW 364.41
Aromatic Rings 1
Heavy Atoms 26
NP-Likeness -0.61

Activity Summary

IC50 6 meas. best 8.05

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Integrin alpha-IIb/beta-3
CHEMBL2093869
IC50 8.05 8.05 9.0 1
Integrin alpha-V/beta-3
CHEMBL1907598
IC50 8.0 7.46 10.0 2
Integrin alpha-V/beta-5
CHEMBL2096675
IC50 7.64 7.64 23.0 1
Integrin alpha-V/beta-1
CHEMBL2111407
IC50 6.5 6.5 317.0 1
Integrin alpha-5/beta-1
CHEMBL2095226
IC50 4.16 4.16 70000.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
24568695 10.1021/jm5000547 Integrin alpha-V/beta-3 2
24568695 10.1021/jm5000547 Integrin alpha-IIb/beta-3 1
24568695 10.1021/jm5000547 Integrin alpha-5/beta-1 1
24568695 10.1021/jm5000547 Integrin alpha-V/beta-1 1
24568695 10.1021/jm5000547 Integrin alpha-V/beta-5 1

Data from ChEMBL 36 via Core Engine