Compound Detail
CHEMBL334073
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Basic Information
| ChEMBL ID | CHEMBL334073 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | OMODHEKCMZABQT-UHFFFAOYSA-N |
2
Targets
2
Activities
2
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
489.4
MW (Da)
3.96
ALogP
4
HBA
1
HBD
69.3
PSA (Ų)
0.57
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 6.4
IC50 1 meas. best 7.35
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Protein farnesyltransferase CHEMBL2094108 | IC50 | 7.35 | 7.35 | 45.0 | 1 |
| NIH3T3 CHEMBL614822 | EC50 | 6.4 | 6.4 | 400.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Protein farnesyltransferase | IC50 | = | 45.0 | nM | 7.35 | Inhibition of purified recombinant human farnesyltransferase (FT) | 11020273 |
| NIH3T3 | EC50 | = | 400.0 | nM | 6.4 | Inhibition of anchorage independent growth of H-ras transformed NIH3T3 cells in ... | 11020273 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 11020273 | 10.1021/jm000248z | Protein farnesyltransferase | 2 |
| 11020273 | 10.1021/jm000248z | NIH3T3 | 1 |
Data from ChEMBL 36 via Core Engine