Compound Detail
CHEMBL339083
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Basic Information
| ChEMBL ID | CHEMBL339083 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SJSUBWZFLWXJFL-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
337.4
MW (Da)
5.83
ALogP
3
HBA
0
HBD
74.5
PSA (Ų)
0.27
QED
1
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 9.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 3',5'-cyclic-AMP phosphodiesterase 4A CHEMBL254 | IC50 | 9.7 | 9.7 | 0.2 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 3',5'-cyclic-AMP phosphodiesterase 4A | IC50 | = | 0.2 | nM | 9.7 | Inhibition of recombinant human PDE4A expressed in Sf9 cells | 11052785 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 11052785 | 10.1021/jm000065c | 3',5'-cyclic-AMP phosphodiesterase 4A | 1 |
| 11052785 | 10.1021/jm000065c | Phosphodiesterase 4 | 1 |
Data from ChEMBL 36 via Core Engine