Compound Detail
CHEMBL3407553
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Basic Information
| ChEMBL ID | CHEMBL3407553 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | OPQRFPHLZZPCCH-PGMHBOJBSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
397.6
MW (Da)
4.46
ALogP
4
HBA
0
HBD
59.0
PSA (Ų)
0.57
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 1 meas. best 6.4
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Ubiquitin carboxyl-terminal hydrolase isozyme L1 CHEMBL6159 | Ki | 6.4 | 6.4 | 400.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Ubiquitin carboxyl-terminal hydrolase isozyme L1 | Ki | = | 400.0 | nM | 6.4 | Competitive inhibition of UCHL1 in human H1299 cells using Ub-AMC substrate | 31682427 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 25364867 | 10.1021/jm501061a | Unchecked | 1 |
| 25364867 | 10.1021/jm501061a | Ubiquitin carboxyl-terminal hydrolase isozyme L1 | 1 |
| 31682427 | 10.1021/acs.jmedchem.9b01138 | Ubiquitin carboxyl-terminal hydrolase isozyme L1 | 1 |
| 35427739 | 10.1016/j.bmcl.2022.128732 | Replicase polyprotein 1ab | 1 |
Data from ChEMBL 36 via Core Engine