Compound Detail
CHEMBL340801
PERLAPINE 🧪 Phase II
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🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL340801 |
| Name | PERLAPINE |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | PWRPUAKXMQAFCJ-UHFFFAOYSA-N |
2
Targets
2
Activities
2
Assay Types
0
PK Parameters
3
Publications
7
Known Names
Molecular Properties
291.4
MW (Da)
2.92
ALogP
3
HBA
0
HBD
18.8
PSA (Ų)
0.74
QED
0
Ro5 Violations
0
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Achiral |
Activity Summary
IC50 1 meas. best 5.57
Ki 1 meas. best 5.32
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| D(2) dopamine receptor CHEMBL339 | IC50 | 5.57 | 5.57 | 2700.0 | 1 |
| Histamine H4 receptor CHEMBL3759 | Ki | 5.32 | 5.32 | 4786.3 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| D(2) dopamine receptor | IC50 | = | 2700.0 | nM | 5.57 | Inhibition of spiropiperidone binding at dopamine receptor D2 of rat. | 11462978 |
| Histamine H4 receptor | Ki | = | 4786.3 | nM | 5.32 | Displacement of [3H]histamine from human histamine H4 receptor transfected in SK... | 16854056 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 11462978 | 10.1021/jm000242+ | Mus musculus | 10 |
| 11462978 | 10.1021/jm000242+ | D(2) dopamine receptor | 1 |
| 16854056 | 10.1021/jm051008s | Histamine H4 receptor | 1 |
Data from ChEMBL 36 via Core Engine