Compound Detail
CHEMBL3425697
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Basic Information
| ChEMBL ID | CHEMBL3425697 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ARMHCDAHKQVAOY-JLHYYAGUSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
417.0
MW (Da)
5.97
ALogP
4
HBA
1
HBD
41.0
PSA (Ų)
0.30
QED
1
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 5.76
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Receptor-type tyrosine-protein kinase FLT3 CHEMBL1974 | IC50 | 5.76 | 5.76 | 1750.0 | 1 |
| Cell division protein FtsZ CHEMBL3999 | IC50 | 4.19 | 4.19 | 65000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Receptor-type tyrosine-protein kinase FLT3 | IC50 | = | 1750.0 | nM | 5.76 | Inhibition of FLT3 ITD mutant (unknown origin) using TAMRA-Src-tide as substrate... | 31614258 |
| Cell division protein FtsZ | IC50 | = | 65000.0 | nM | 4.19 | Inhibition of Escherichia coli FtsZ GTPase activity after 5 mins by enzyme-coupl... | 25815151 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 25815151 | 10.1021/ml500497s | Cell division protein FtsZ | 1 |
| 31614258 | 10.1016/j.ejmech.2019.111710 | Receptor-type tyrosine-protein kinase FLT3 | 1 |
Data from ChEMBL 36 via Core Engine