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Assay Detail

CHEMBL3429345

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of Escherichia coli FtsZ GTPase activity after 5 mins by enzyme-coupled inhibition assay
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Escherichia coli
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Cell division protein FtsZ (CHEMBL3999)
Type SINGLE PROTEIN
Organism Escherichia coli K-12

Publication

Synthesis and Evaluation of Quinazolines as Inhibitors of the Bacterial Cell Division Protein FtsZ.
Nepomuceno GM, Chan KM, Huynh V, Martin KS, Moore JT, O'Brien TE, Pollo LA, Sarabia FJ, Tadeus C, Yao Z, Anderson DE, Ames JB, Shaw JT.
ACS Med Chem Lett (2015) 6 : 308 -312
PubMed 25815151 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 30 4.44 5.05

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3425702 1 5.05
CHEMBL3425706 1 4.85
CHEMBL3425705 1 4.62
CHEMBL3425606 1 4.62
CHEMBL3425694 1 4.58
CHEMBL3425693 1 4.57
CHEMBL3425611 1 4.55
CHEMBL3425612 1 4.52
CHEMBL3425609 1 4.52
CHEMBL3425615 1 4.31
CHEMBL3425701 1 4.28
CHEMBL3425613 1 4.24
CHEMBL3425697 1 4.19
CHEMBL3425704 1 4.07
CHEMBL3425610 1 4.02
CHEMBL3425608 1 4.00
CHEMBL3425607 1 -
CHEMBL3425605 1 -
CHEMBL3425604 1 -
CHEMBL3425614 1 -
CHEMBL3425689 1 -
CHEMBL3425690 1 -
CHEMBL3425691 1 -
CHEMBL3425692 1 -
CHEMBL3425695 1 -
CHEMBL3425696 1 -
CHEMBL3425698 1 -
CHEMBL3425699 1 -
CHEMBL3425700 1 -
CHEMBL3425703 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3425702 IC50 = 9000.0 nM 5.05
CHEMBL3425706 IC50 = 14000.0 nM 4.85
CHEMBL3425705 IC50 = 24000.0 nM 4.62
CHEMBL3425606 IC50 = 24000.0 nM 4.62
CHEMBL3425694 IC50 = 26000.0 nM 4.58
CHEMBL3425693 IC50 = 27000.0 nM 4.57
CHEMBL3425611 IC50 = 28000.0 nM 4.55
CHEMBL3425612 IC50 = 30000.0 nM 4.52
CHEMBL3425609 IC50 = 30000.0 nM 4.52
CHEMBL3425615 IC50 = 49000.0 nM 4.31
CHEMBL3425701 IC50 = 52000.0 nM 4.28
CHEMBL3425613 IC50 = 58000.0 nM 4.24
CHEMBL3425697 IC50 = 65000.0 nM 4.19
CHEMBL3425704 IC50 = 85000.0 nM 4.07
CHEMBL3425610 IC50 = 95000.0 nM 4.02
CHEMBL3425608 IC50 = 100000.0 nM 4.00
CHEMBL3425607 IC50 > 128000.0 nM -
CHEMBL3425605 IC50 > 128000.0 nM -
CHEMBL3425604 IC50 > 128000.0 nM -
CHEMBL3425614 IC50 > 128000.0 nM -
CHEMBL3425689 IC50 > 128000.0 nM -
CHEMBL3425690 IC50 > 128000.0 nM -
CHEMBL3425691 IC50 > 128000.0 nM -
CHEMBL3425692 IC50 > 128000.0 nM -
CHEMBL3425695 IC50 > 128000.0 nM -
CHEMBL3425696 IC50 > 128000.0 nM -
CHEMBL3425698 IC50 > 128000.0 nM -
CHEMBL3425699 IC50 > 128000.0 nM -
CHEMBL3425700 IC50 > 128000.0 nM -
CHEMBL3425703 IC50 > 128000.0 nM -