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Compound Detail

CHEMBL343055

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CN1CCC=C(c2nsnc2SCCSc2nsnc2C2=CCCN(C)C2)C1

Basic Information

ChEMBL ID CHEMBL343055
Phase Preclinical
Structure Type MOL
InChI Key CBWXXWKUMAETMN-UHFFFAOYSA-N
1
Targets
2
Activities
2
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

452.7
MW (Da)
3.71
ALogP
10
HBA
0
HBD
58.0
PSA (Ų)
0.47
QED
0
Ro5 Violations
7
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C18H24N6S4
MW 452.70
Aromatic Rings 2
Heavy Atoms 28
NP-Likeness -0.44

Activity Summary

EC50 1 meas. best 6.36
Ki 1 meas. best 7.7

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Muscarinic acetylcholine receptor M1
CHEMBL216
Ki 7.7 7.7 20.0 1
Muscarinic acetylcholine receptor M1
CHEMBL216
EC50 6.36 6.36 440.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
11741475 10.1021/jm0102405 Muscarinic acetylcholine receptor M1 3

Data from ChEMBL 36 via Core Engine