Skip to main content
Free research Free research Free compound review with research home and workspace preview
Quick search ChEMBL 36
Compound Detail

CHEMBL348865

Enter ChEMBL ID:
Free Research Context This compound will appear in recent viewed items on the research home for this browser.
Research home View demo workspace
COc1ccc2c(ccn2Nc2ccncc2)c1

Basic Information

ChEMBL ID CHEMBL348865
Phase Preclinical
Structure Type MOL
InChI Key OLLIUPXULGNHBZ-UHFFFAOYSA-N
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

239.3
MW (Da)
2.92
ALogP
4
HBA
1
HBD
39.1
PSA (Ų)
0.76
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C14H13N3O
MW 239.28
Aromatic Rings 3
Heavy Atoms 18
NP-Likeness -1.12

Activity Summary

IC50 2 meas. best 5.12

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Muscarinic acetylcholine receptor
CHEMBL1907609
IC50 5.12 4.74 7500.0 2

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
8558529 10.1021/jm9506433 Muscarinic acetylcholine receptor 3
8558529 10.1021/jm9506433 Mus musculus 2
8558529 10.1021/jm9506433 Acetylcholinesterase 1
8558529 10.1021/jm9506433 Sodium-dependent noradrenaline transporter 1

Data from ChEMBL 36 via Core Engine