Assay Detail
Binding
CHEMBL744136
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]quinuclidinyl benzilate (QNB) binding from rat forebrain membranes in the absence of Zn
42
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Subcellular | Membrane |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor (CHEMBL1907609) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Synthesis and structure-activity relationships of N-propyl-N-(4-pyridinyl)-1H-indol-1-amine (besipirdine) and related analogs as potential therapeutic agents for Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 42 | 5.03 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL569713 | SCOPOLAMINE | 4.0 | 1 | 8.40 |
| CHEMBL7634 | OXOTREMORINE | — | 1 | 5.57 |
| CHEMBL154228 | — | — | 1 | 5.57 |
| CHEMBL29835 | BESIPIRDINE | 2.0 | 1 | 5.52 |
| CHEMBL155603 | — | — | 1 | 5.48 |
| CHEMBL155109 | — | — | 1 | 5.40 |
| CHEMBL347914 | — | — | 1 | 5.36 |
| CHEMBL347666 | — | — | 1 | 5.34 |
| CHEMBL435034 | — | — | 1 | 5.26 |
| CHEMBL155460 | — | — | 1 | 5.24 |
| CHEMBL154319 | — | — | 1 | 5.22 |
| CHEMBL347336 | — | — | 1 | 5.14 |
| CHEMBL154945 | — | — | 1 | 5.14 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 5.14 |
| CHEMBL345442 | — | — | 1 | 5.07 |
| CHEMBL152842 | — | — | 1 | 5.05 |
| CHEMBL154541 | — | — | 1 | 5.00 |
| CHEMBL348034 | — | — | 1 | 4.96 |
| CHEMBL346142 | — | — | 1 | 4.89 |
| CHEMBL155211 | — | — | 1 | 4.85 |
| CHEMBL350692 | — | — | 1 | 4.72 |
| CHEMBL345607 | — | — | 1 | 4.70 |
| CHEMBL154257 | — | — | 1 | 4.54 |
| CHEMBL157902 | — | — | 1 | 4.54 |
| CHEMBL154488 | — | — | 1 | 4.40 |
| CHEMBL357553 | — | — | 1 | 4.38 |
| CHEMBL152362 | — | — | 1 | 4.36 |
| CHEMBL348865 | — | — | 1 | 4.36 |
| CHEMBL154297 | — | — | 1 | 4.22 |
| CHEMBL351760 | — | — | 1 | 4.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL569713 | SCOPOLAMINE | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL7634 | OXOTREMORINE | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL154228 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL29835 | BESIPIRDINE | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL155603 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL155109 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL347914 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL347666 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL435034 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL155460 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL154319 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL154945 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL95 | TACRINE | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL347336 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL345442 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL152842 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL154541 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL348034 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL346142 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL155211 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL350692 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL345607 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL157902 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL154257 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL154488 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL357553 | — | IC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL152362 | — | IC50 | = | 44000.0 | nM | 4.36 |
| CHEMBL348865 | — | IC50 | = | 44000.0 | nM | 4.36 |
| CHEMBL154297 | — | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL351760 | — | IC50 | = | 82000.0 | nM | 4.09 |
| CHEMBL345439 | — | IC50 | = | 91000.0 | nM | 4.04 |
| CHEMBL348716 | — | IC50 | = | 409000.0 | nM | - |
| CHEMBL346021 | — | IC50 | = | 223000.0 | nM | - |
| CHEMBL155359 | — | IC50 | = | 128000.0 | nM | - |
| CHEMBL347199 | — | IC50 | = | 142000.0 | nM | - |
| CHEMBL345251 | — | IC50 | = | 391000.0 | nM | - |
| CHEMBL356922 | — | IC50 | = | 146000.0 | nM | - |
| CHEMBL157971 | — | IC50 | = | 127000.0 | nM | - |
| CHEMBL347933 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL152748 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL153847 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL154735 | — | IC50 | > | 1000000.0 | nM | - |