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Compound Detail

CHEMBL357553

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Clc1ccc2c(ccn2Nc2ccncc2)c1

Basic Information

ChEMBL ID CHEMBL357553
Phase Preclinical
Structure Type MOL
InChI Key SDCIJOLMGUGDKZ-UHFFFAOYSA-N
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

243.7
MW (Da)
3.56
ALogP
3
HBA
1
HBD
29.9
PSA (Ų)
0.75
QED
0
Ro5 Violations
2
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C13H10ClN3
MW 243.70
Aromatic Rings 3
Heavy Atoms 17
NP-Likeness -1.59

Activity Summary

IC50 2 meas. best 5.23

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Muscarinic acetylcholine receptor
CHEMBL1907609
IC50 5.23 4.805 5900.0 2

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
8558529 10.1021/jm9506433 Muscarinic acetylcholine receptor 3
8558529 10.1021/jm9506433 Mus musculus 2
8558529 10.1021/jm9506433 Acetylcholinesterase 1
8558529 10.1021/jm9506433 Sodium-dependent noradrenaline transporter 1

Data from ChEMBL 36 via Core Engine