Compound Detail
CHEMBL3526986
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL3526986 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | PNFMEGSMKIHDFZ-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
546.1
MW (Da)
5.92
ALogP
3
HBA
1
HBD
50.4
PSA (Ų)
0.32
QED
2
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 5.51
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Eyes absent homolog 3 CHEMBL4296245 | IC50 | 5.51 | 5.51 | 3100.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Eyes absent homolog 3 | IC50 | = | 3100.0 | nM | 5.51 | Inhibition of human Eya3 isoform 2 (127 to 573 residues) incubated for 30 mins b... | - |
| Eyes absent homolog 3 | IC50 | = | 3100.0 | nM | 5.51 | Inhibition of poly-histidine and GST-tagged full length human Eya3 isoform 2 (12... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 21398391 | 10.1124/dmd.110.037671 | ADMET | 2 |
| 21398391 | 10.1124/dmd.110.037671 | No relevant target | 1 |
| 21398391 | 10.1124/dmd.110.037671 | Liver microsome | 1 |
Data from ChEMBL 36 via Core Engine