Assay Detail
Binding
CHEMBL4422501
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of poly-histidine and GST-tagged full length human Eya3 isoform 2 (127 to 573 residues) using para-nitrophenol phosphate substrate incubated for 30 mins
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Use of small molecule inhibitors targeting EYA tyrosine phosphatase
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 4.77 | 5.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3526986 | — | — | 1 | 5.51 |
| CHEMBL232201 | BENZIODARONE | 4.0 | 1 | 5.47 |
| CHEMBL389052 | — | — | 1 | 5.08 |
| CHEMBL388590 | BENZBROMARONE | 4.0 | 1 | 5.08 |
| CHEMBL4290672 | — | — | 1 | 4.86 |
| CHEMBL1523279 | — | — | 1 | 4.82 |
| CHEMBL4281427 | — | — | 1 | 4.79 |
| CHEMBL1474963 | BENZARONE | 4.0 | 1 | 4.77 |
| CHEMBL4287926 | — | — | 1 | 4.76 |
| CHEMBL1767079 | — | — | 1 | 4.57 |
| CHEMBL1767107 | — | — | 1 | 4.39 |
| CHEMBL224006 | POZTINURAD | 2.0 | 1 | 4.38 |
| CHEMBL1767090 | — | — | 1 | 4.14 |
| CHEMBL374618 | — | — | 1 | 4.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3526986 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL232201 | BENZIODARONE | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL389052 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL388590 | BENZBROMARONE | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL4290672 | — | IC50 | = | 13800.0 | nM | 4.86 |
| CHEMBL1523279 | — | IC50 | = | 15200.0 | nM | 4.82 |
| CHEMBL4281427 | — | IC50 | = | 16400.0 | nM | 4.79 |
| CHEMBL1474963 | BENZARONE | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL4287926 | — | IC50 | = | 17500.0 | nM | 4.76 |
| CHEMBL1767079 | — | IC50 | = | 27200.0 | nM | 4.57 |
| CHEMBL1767107 | — | IC50 | = | 40800.0 | nM | 4.39 |
| CHEMBL224006 | POZTINURAD | IC50 | = | 41900.0 | nM | 4.38 |
| CHEMBL1767090 | — | IC50 | = | 73100.0 | nM | 4.14 |
| CHEMBL374618 | — | IC50 | = | 81100.0 | nM | 4.09 |