Eyes absent homolog 3 · SINGLE PROTEIN · Homo sapiens
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Structured disease, protein, and project context should read before the lower-level identity rail.
As of 2026-09-14Protein identity stays anchored to UniProt Q99504. Use UniProt Q99504 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q99504 as the stable identity anchor, then attach disease evidence before program review.
Protein phosphatase EYA3
Review this target as Eyes absent homolog 3, mapped to UniProt Q99504. ChEMBL maps the protein component as Protein phosphatase EYA3. Sequence length is 573 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Eyes absent homolog 3 as ChEMBL target CHEMBL4296245, mapped to UniProt Q99504. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Eyes absent homolog 3 is the right protein anchor across sources, using UniProt Q99504 as the stable mapping.
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| Preferred Name | Eyes absent homolog 3 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q99504 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Protein phosphatase EYA3 |
| UniProt Accession | Q99504 |
| Component Type | Protein |
| Sequence Length | 573 aa |
Protein phosphatase EYA3
Review this target as Eyes absent homolog 3, mapped to UniProt Q99504. ChEMBL maps the protein component as Protein phosphatase EYA3. Sequence length is 573 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3526986 | 5.51 | IC50 | 3100.0 | Preclinical |
| CHEMBL232201 | 5.47 | IC50 | 3400.0 | Approved |
| CHEMBL388590 | 5.08 | IC50 | 8300.0 | Approved |
| CHEMBL389052 | 5.08 | IC50 | 8300.0 | Preclinical |
| CHEMBL1523279 | 5.0 | IC50 | 10100.0 | Preclinical |
| CHEMBL4290672 | 4.86 | IC50 | 13800.0 | Preclinical |
| CHEMBL4281427 | 4.79 | IC50 | 16400.0 | Preclinical |
| CHEMBL1474963 | 4.77 | IC50 | 17000.0 | Approved |
| CHEMBL4287926 | 4.76 | IC50 | 17500.0 | Preclinical |
| CHEMBL1767079 | 4.57 | IC50 | 27200.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 10 | 14 | 4.7 |
| assay format | 7 | 14 | 4.7 |