Compound Detail
CHEMBL4281427
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Basic Information
| ChEMBL ID | CHEMBL4281427 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VHPZHWQAFHIRNX-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
562.1
MW (Da)
4.89
ALogP
4
HBA
2
HBD
70.7
PSA (Ų)
0.34
QED
1
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 4.79
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Eyes absent homolog 3 CHEMBL4296245 | IC50 | 4.79 | 4.79 | 16400.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Eyes absent homolog 3 | IC50 | = | 16400.0 | nM | 4.79 | Inhibition of human Eya3 isoform 2 (127 to 573 residues) incubated for 30 mins b... | - |
| Eyes absent homolog 3 | IC50 | = | 16400.0 | nM | 4.79 | Inhibition of poly-histidine and GST-tagged full length human Eya3 isoform 2 (12... | - |
Data from ChEMBL 36 via Core Engine