Compound Detail
CHEMBL1767090
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Basic Information
| ChEMBL ID | CHEMBL1767090 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | CGUSGHJDNCSDGH-UHFFFAOYSA-N |
2
Targets
5
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
282.3
MW (Da)
3.64
ALogP
4
HBA
2
HBD
70.7
PSA (Ų)
0.72
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 5 meas. best 5.6
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Solute carrier family 22 member 12 CHEMBL6120 | IC50 | 5.6 | 5.6 | 2490.0 | 1 |
| Eyes absent homolog 3 CHEMBL4296245 | IC50 | 4.14 | 4.14 | 73100.0 | 4 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Solute carrier family 22 member 12 | IC50 | = | 2490.0 | nM | 5.6 | Inhibition of human URAT1 expressed in xenopus oocyte assessed as inhibition of ... | 21449597 |
| Eyes absent homolog 3 | IC50 | = | 73100.0 | nM | 4.14 | Inhibition of human Eya3 isoform 2 (127 to 573 residues) incubated for 30 mins b... | - |
| Eyes absent homolog 3 | IC50 | = | 73100.0 | nM | 4.14 | Inhibition of poly-histidine and GST-tagged full length human Eya3 isoform 2 (12... | - |
| Eyes absent homolog 3 | IC50 | = | 73100.0 | nM | 4.14 | Inhibitory Assay: An inhibitory assay was conducted using the previously describ... | - |
| Eyes absent homolog 3 | IC50 | = | 73100.0 | nM | 4.14 | Inhibition Assay: The compounds were then tested using full-length human recombi... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 21449597 | 10.1021/jm1015022 | Solute carrier family 22 member 12 | 2 |
Data from ChEMBL 36 via Core Engine