Compound Detail
CHEMBL3545403
BMS-833923 🧪 Phase II
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL3545403 |
| Name | BMS-833923 |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | KLRRGBHZCJLIEL-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
8
Publications
5
Known Names
7
Indications
1
Mechanisms
Molecular Properties
473.6
MW (Da)
6.32
ALogP
5
HBA
3
HBD
78.9
PSA (Ų)
0.26
QED
1
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Achiral |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Smoothened homolog antagonist | ANTAGONIST | Protein smoothened | ✓ | ✓ |
Indications
Leukemia Basal Cell Nevus Syndrome Carcinoma, Basal Cell Esophageal Neoplasms Neoplasms Small Cell Lung Carcinoma Stomach Neoplasms
Activity Summary
IC50 2 meas. best 5.6
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Schistosoma mansoni CHEMBL612893 | IC50 | 5.6 | 5.53 | 2500.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Schistosoma mansoni | IC50 | = | 2500.0 | nM | 5.6 | Antischistosomal activity against Schistosoma mansoni incubated for 72 hrs by in... | 33479649 |
| Schistosoma mansoni | IC50 | = | 3500.0 | nM | 5.46 | Antischistosomal activity against Schistosoma mansoni Liberian NTS incubated for... | 33479649 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.6019/CHEMBL4651402 | SARS-CoV-2 | 4 |
| 33479649 | 10.1039/D0MD00062K | Schistosoma mansoni | 3 |
| - | 10.6019/CHEMBL4495565 | SARS-CoV-2 | 2 |
| - | 10.6019/CHEMBL4651402 | Vero C1008 | 2 |
| - | 10.6019/CHEMBL4808148 | Histone deacetylase 6 | 2 |
| - | 10.21203/rs.3.rs-23951/v1 | SARS-CoV-2 | 1 |
| - | 10.6019/CHEMBL4495564 | Replicase polyprotein 1ab | 1 |
| 24973920 | 10.1038/nm.3613 | Medulloblastoma cell | 1 |
Data from ChEMBL 36 via Core Engine