Compound Detail
CHEMBL3589689
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Basic Information
| ChEMBL ID | CHEMBL3589689 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SCEGFUSFDRBYJA-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
454.4
MW (Da)
3.67
ALogP
4
HBA
2
HBD
63.1
PSA (Ų)
0.36
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 5.6
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Nucleophosmin CHEMBL5178 | EC50 | 5.6 | 5.6 | 2500.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Nucleophosmin | EC50 | = | 2500.0 | nM | 5.6 | Inhibition of phosphorylated NPM1 recruitment to chromatic in 6 Gy irradiated hu... | 25922180 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 25922180 | 10.1016/j.bmc.2015.04.018 | Nucleophosmin | 3 |
| 26602084 | 10.1016/j.bmc.2015.10.019 | NON-PROTEIN TARGET | 2 |
| 25922180 | 10.1016/j.bmc.2015.04.018 | NCI-H460 | 1 |
Data from ChEMBL 36 via Core Engine