Compound Detail
CHEMBL360621
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Basic Information
| ChEMBL ID | CHEMBL360621 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | KGPVSHDYABSPDA-NUOLXNBNSA-P |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
460.6
MW (Da)
5.98
ALogP
2
HBA
2
HBD
31.8
PSA (Ų)
0.28
QED
1
Ro5 Violations
0
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.22
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Small conductance calcium-activated potassium channel CHEMBL2096673 | IC50 | 7.22 | 7.22 | 60.0 | 1 |
| Small conductance calcium-activated potassium channel protein 3 CHEMBL3381 | IC50 | 7.22 | 7.22 | 60.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Small conductance calcium-activated potassium channel | IC50 | = | 60.0 | nM | 7.22 | Inhibition of after hyperpolarization (AHP) of cultured rat sympathetic neurons ... | 15261276 |
| Small conductance calcium-activated potassium channel protein 3 | IC50 | = | 60.0 | nM | 7.22 | Inhibition of KCa2.3 (unknown origin) | 23685886 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15261276 | 10.1016/j.bmcl.2004.06.011 | Small conductance calcium-activated potassium channel | 1 |
| 23685886 | 10.1016/j.ejmech.2013.02.029 | Small conductance calcium-activated potassium channel protein 3 | 1 |
Data from ChEMBL 36 via Core Engine