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Compound Detail

CHEMBL362136

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C[C@H](Cc1c[nH]c2c(OCCN)cccc12)NC[C@H](O)c1cccc(NS(=O)(=O)c2cccs2)c1

Basic Information

ChEMBL ID CHEMBL362136
Phase Preclinical
Structure Type MOL
InChI Key SHMZYLNMPWDEBQ-VGSWGCGISA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

514.7
MW (Da)
3.62
ALogP
7
HBA
5
HBD
129.5
PSA (Ų)
0.20
QED
1
Ro5 Violations
12
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C25H30N4O4S2
MW 514.67
Aromatic Rings 4
Heavy Atoms 35
NP-Likeness -1.08

Activity Summary

EC50 2 meas. best 8.37

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Beta-3 adrenergic receptor
CHEMBL246
EC50 8.37 8.37 4.3 1
Beta-1 adrenergic receptor
CHEMBL213
EC50 7.54 7.54 29.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
15546707 10.1016/j.bmcl.2004.10.035 Beta-3 adrenergic receptor 2
15546707 10.1016/j.bmcl.2004.10.035 Beta-1 adrenergic receptor 2
15546707 10.1016/j.bmcl.2004.10.035 Beta-2 adrenergic receptor 2

Data from ChEMBL 36 via Core Engine