Assay Detail
Functional
CHEMBL833517
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Agonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptor
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Tryptamine-based human beta3-adrenergic receptor agonists. Part 1: SAR studies of the 7-position of the indole ring.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 15 | 7.36 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL185703 | — | — | 1 | 7.72 |
| CHEMBL186135 | — | — | 1 | 7.70 |
| CHEMBL189081 | — | — | 1 | 7.66 |
| CHEMBL187317 | — | — | 1 | 7.58 |
| CHEMBL361505 | — | — | 1 | 7.54 |
| CHEMBL362136 | — | — | 1 | 7.54 |
| CHEMBL185660 | — | — | 1 | 7.40 |
| CHEMBL184407 | — | — | 1 | 7.36 |
| CHEMBL186271 | — | — | 1 | 7.31 |
| CHEMBL186676 | — | — | 1 | 7.27 |
| CHEMBL186236 | — | — | 1 | 7.24 |
| CHEMBL185836 | — | — | 1 | 7.18 |
| CHEMBL187209 | — | — | 1 | 7.14 |
| CHEMBL362763 | — | — | 1 | 7.07 |
| CHEMBL188196 | — | — | 1 | 6.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL185703 | — | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL186135 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL189081 | — | EC50 | = | 22.0 | nM | 7.66 |
| CHEMBL187317 | — | EC50 | = | 26.0 | nM | 7.58 |
| CHEMBL361505 | — | EC50 | = | 29.0 | nM | 7.54 |
| CHEMBL362136 | — | EC50 | = | 29.0 | nM | 7.54 |
| CHEMBL185660 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL184407 | — | EC50 | = | 44.0 | nM | 7.36 |
| CHEMBL186271 | — | EC50 | = | 49.0 | nM | 7.31 |
| CHEMBL186676 | — | EC50 | = | 54.0 | nM | 7.27 |
| CHEMBL186236 | — | EC50 | = | 58.0 | nM | 7.24 |
| CHEMBL185836 | — | EC50 | = | 66.0 | nM | 7.18 |
| CHEMBL187209 | — | EC50 | = | 72.0 | nM | 7.14 |
| CHEMBL362763 | — | EC50 | = | 85.0 | nM | 7.07 |
| CHEMBL188196 | — | EC50 | = | 180.0 | nM | 6.75 |