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Compound Detail

CHEMBL185703

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C[C@H](Cc1c[nH]c2c(OCC(=O)N(C)C)cccc12)NC[C@H](O)c1cccc(NS(=O)(=O)c2cccs2)c1

Basic Information

ChEMBL ID CHEMBL185703
Phase Preclinical
Structure Type MOL
InChI Key IZAYFWKVBBNBFP-JPYJTQIMSA-N
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

556.7
MW (Da)
3.75
ALogP
7
HBA
4
HBD
123.8
PSA (Ų)
0.21
QED
1
Ro5 Violations
12
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C27H32N4O5S2
MW 556.71
Aromatic Rings 4
Heavy Atoms 38
NP-Likeness -1.47

Activity Summary

EC50 3 meas. best 8.89

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Beta-3 adrenergic receptor
CHEMBL246
EC50 8.89 8.89 1.3 1
Beta-2 adrenergic receptor
CHEMBL210
EC50 8.17 8.17 6.8 1
Beta-1 adrenergic receptor
CHEMBL213
EC50 7.72 7.72 19.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
15546707 10.1016/j.bmcl.2004.10.035 Beta-2 adrenergic receptor 2
15546707 10.1016/j.bmcl.2004.10.035 Beta-3 adrenergic receptor 2
15546707 10.1016/j.bmcl.2004.10.035 Beta-1 adrenergic receptor 2

Data from ChEMBL 36 via Core Engine