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Compound Detail

CHEMBL366154

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CC1=C2C[C@H]3[C@@H](CC=C4C[C@@H](O)CC[C@@]43C)[C@@H]2CC[C@]12O[C@]1(C)C[C@H](C)CN[C@H]1[C@H]2C

Basic Information

ChEMBL ID CHEMBL366154
Phase Preclinical
Structure Type MOL
InChI Key RAHCWWLGPKNZDP-ZBABXINMSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

425.7
MW (Da)
5.39
ALogP
3
HBA
2
HBD
41.5
PSA (Ų)
0.51
QED
1
Ro5 Violations
0
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C28H43NO2
MW 425.66
Aromatic Rings 0
Heavy Atoms 31
NP-Likeness 2.67

Activity Summary

Ki 2 meas. best 6.3

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
C-8 sterol isomerase ERG2
CHEMBL3224
Ki 6.3 6.3 500.0 1
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase
CHEMBL4931
Ki 6.18 6.18 654.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
16033255 10.1021/jm049073+ 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase 1
16033255 10.1021/jm049073+ Sigma non-opioid intracellular receptor 1 1
16033255 10.1021/jm049073+ C-8 sterol isomerase ERG2 1

Data from ChEMBL 36 via Core Engine