Assay Detail
Binding
CHEMBL829736
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Affinity for human EMP expressed in ERG2 deficient strain of Saccharomyces cerevisiae using [3H]ifenprodil or (+)-[3H]pentazocine as radioligand
44
Total Activities
44
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (CHEMBL4931) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of high-affinity ligands of sigma1 receptor, ERG2, and emopamil binding protein by pharmacophore modeling and virtual screening.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 44 | 7.42 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL17470 | — | — | 1 | 9.22 |
| CHEMBL28211 | NAFOXIDINE | 2.0 | 1 | 9.05 |
| CHEMBL81 | RALOXIFENE | 4.0 | 1 | 9.00 |
| CHEMBL365842 | — | — | 1 | 9.00 |
| CHEMBL62540 | — | — | 1 | 9.00 |
| CHEMBL954 | ENCLOMIPHENE | 3.0 | 1 | 9.00 |
| CHEMBL363884 | RONIPAMIL | 2.0 | 1 | 8.70 |
| CHEMBL365141 | — | — | 1 | 8.70 |
| CHEMBL167779 | ZUCLOMIPHENE | 2.0 | 1 | 8.70 |
| CHEMBL188476 | — | — | 1 | 8.52 |
| CHEMBL361085 | — | — | 1 | 8.40 |
| CHEMBL113830 | (S,R)-IFENPRODIL | — | 1 | 8.30 |
| CHEMBL83 | TAMOXIFEN | 4.0 | 1 | 8.30 |
| CHEMBL187615 | — | — | 1 | 8.22 |
| CHEMBL422 | TRIFLUOPERAZINE | 4.0 | 1 | 8.10 |
| CHEMBL187709 | TRIPARANOL | 4.0 | 1 | 7.96 |
| CHEMBL370753 | OPIPRAMOL | 3.0 | 1 | 7.89 |
| CHEMBL190883 | — | — | 1 | 7.82 |
| CHEMBL187829 | LEVEMOPAMIL | 2.0 | 1 | 7.75 |
| CHEMBL633 | AMIODARONE | 4.0 | 1 | 7.60 |
| CHEMBL372700 | FENPROPIMORPH | — | 1 | 7.52 |
| CHEMBL365722 | — | — | 1 | 7.41 |
| CHEMBL188044 | — | — | 1 | 7.29 |
| CHEMBL190631 | — | — | 1 | 7.27 |
| CHEMBL188921 | BUFLOMEDIL | 4.0 | 1 | 7.22 |
| CHEMBL15023 | TRIFLUPERIDOL | 2.0 | 1 | 6.78 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 6.72 |
| CHEMBL363703 | — | — | 1 | 6.36 |
| CHEMBL363765 | — | — | 1 | 6.35 |
| CHEMBL305593 | — | — | 1 | 6.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL17470 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL28211 | NAFOXIDINE | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL365842 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL62540 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL954 | ENCLOMIPHENE | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL81 | RALOXIFENE | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL363884 | RONIPAMIL | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL365141 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL167779 | ZUCLOMIPHENE | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL188476 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL361085 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL83 | TAMOXIFEN | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL113830 | (S,R)-IFENPRODIL | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL187615 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL422 | TRIFLUOPERAZINE | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL187709 | TRIPARANOL | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL370753 | OPIPRAMOL | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL190883 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL187829 | LEVEMOPAMIL | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL633 | AMIODARONE | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL372700 | FENPROPIMORPH | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL365722 | — | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL188044 | — | Ki | = | 51.0 | nM | 7.29 |
| CHEMBL190631 | — | Ki | = | 54.0 | nM | 7.27 |
| CHEMBL188921 | BUFLOMEDIL | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL15023 | TRIFLUPERIDOL | Ki | = | 165.0 | nM | 6.78 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL363703 | — | Ki | = | 441.0 | nM | 6.36 |
| CHEMBL363765 | — | Ki | = | 450.0 | nM | 6.35 |
| CHEMBL305593 | — | Ki | = | 500.0 | nM | 6.30 |
| CHEMBL365417 | — | Ki | = | 583.0 | nM | 6.23 |
| CHEMBL366154 | — | Ki | = | 654.0 | nM | 6.18 |
| CHEMBL626 | NAFTIFINE | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL7393 | — | Ki | = | 2200.0 | nM | 5.66 |
| CHEMBL282433 | DITOLYLGUANIDINE | Ki | = | 6700.0 | nM | 5.17 |
| CHEMBL345754 | — | Ki | = | 8500.0 | nM | 5.07 |
| CHEMBL2368401 | (7S,8R)-6-ALLYLAMINO-7,8-DIMETHYL-8-PROPYL-5,6,7,8-TETRAHYDRO-NAPHTHALEN-2-OL | Ki | = | 9300.0 | nM | 5.03 |
| CHEMBL189871 | — | Ki | = | 34000.0 | nM | 4.47 |
| CHEMBL386630 | TESTOSTERONE | Ki | > | 100000.0 | nM | - |
| CHEMBL186779 | JERVINE | Ki | > | 100000.0 | nM | - |
| CHEMBL372484 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL110739 | CORTICOSTERONE | Ki | > | 100000.0 | nM | - |
| CHEMBL822 | TERBINAFINE | Ki | > | 50000.0 | nM | - |
| CHEMBL103 | PROGESTERONE | Ki | > | 100000.0 | nM | - |