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Compound Detail

CHEMBL189871

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O=C(O)c1ccc(CCN2CCN(C/C=C/c3ccc(Cl)cc3)CC2)cc1

Basic Information

ChEMBL ID CHEMBL189871
Phase Preclinical
Structure Type MOL
InChI Key YQIGCNRBMYEJID-OWOJBTEDSA-N
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

384.9
MW (Da)
3.91
ALogP
3
HBA
1
HBD
43.8
PSA (Ų)
0.79
QED
0
Ro5 Violations
7
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C22H25ClN2O2
MW 384.91
Aromatic Rings 2
Heavy Atoms 27
NP-Likeness -0.75

Activity Summary

Ki 3 meas. best 6.17

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Sigma non-opioid intracellular receptor 1
CHEMBL287
Ki 6.17 6.17 680.0 1
C-8 sterol isomerase ERG2
CHEMBL3224
Ki 4.78 4.78 16480.0 1
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase
CHEMBL4931
Ki 4.47 4.47 34000.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
16033255 10.1021/jm049073+ 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase 1
16033255 10.1021/jm049073+ Sigma non-opioid intracellular receptor 1 1
16033255 10.1021/jm049073+ C-8 sterol isomerase ERG2 1

Data from ChEMBL 36 via Core Engine