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Compound Detail

CHEMBL345754

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N=C(NCc1ccccc1)Nc1nc(-c2cc3ccccc3[nH]2)cs1

Basic Information

ChEMBL ID CHEMBL345754
Phase Preclinical
Structure Type MOL
InChI Key ZPFDTTGBHZESRW-UHFFFAOYSA-N
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

347.4
MW (Da)
4.43
ALogP
3
HBA
4
HBD
76.6
PSA (Ų)
0.33
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C19H17N5S
MW 347.45
Aromatic Rings 4
Heavy Atoms 25
NP-Likeness -1.28

Activity Summary

Ki 3 meas. best 5.07

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase
CHEMBL4931
Ki 5.07 5.07 8500.0 1
Sigma non-opioid intracellular receptor 1
CHEMBL287
Ki 4.57 4.57 26700.0 1
C-8 sterol isomerase ERG2
CHEMBL3224
Ki 4.5 4.5 31700.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
16033255 10.1021/jm049073+ 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase 1
16033255 10.1021/jm049073+ Sigma non-opioid intracellular receptor 1 1
16033255 10.1021/jm049073+ C-8 sterol isomerase ERG2 1

Data from ChEMBL 36 via Core Engine