Compound Detail

CHEMBL363884

RONIPAMIL

🧪 Phase II

Enter ChEMBL ID:

Free Research Context This compound will appear in recent viewed items on the research home for this browser.

🧪 Phase II

CCCCCCCCCCCCC(C#N)(CCCN(C)CCc1ccccc1)c1ccccc1

ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID	CHEMBL363884
Name	RONIPAMIL
Phase	Phase II
Structure Type	MOL
InChI Key	KLBJRPVUPJXXCM-UHFFFAOYSA-N

Ronipamil Ronipamilo

Targets

Activities

Assay Types

PK Parameters

Publications

Known Names

460.8

MW (Da)

8.71

ALogP

HBA

HBD

27.0

PSA (Å²)

0.20

QED

Ro5 Violations

Rot. Bonds

Molecule Type	Small molecule
Chirality	Racemic

USAN Stem

-pamil

Ki 3 meas. best 9.0

Target	Type	Best pChEMBL	Mean pChEMBL	Best (nM)	# Data
Sigma non-opioid intracellular receptor 1 CHEMBL287	Ki	9.0	9.0	1.0	1
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase CHEMBL4931	Ki	8.7	8.7	2.0	1
C-8 sterol isomerase ERG2 CHEMBL3224	Ki	7.89	7.89	13.0	1

Top measurements by pChEMBL value

Target	Type	Rel.	Value	Units	pChEMBL	Assay	PubMed
Sigma non-opioid intracellular receptor 1	Ki	=	1.0	nM	9.0	Affinity for sigma receptor type 1 of guinea pig using [3H]ifenprodil or (+)-[3H...	16033255
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	Ki	=	2.0	nM	8.7	Affinity for human EMP expressed in ERG2 deficient strain of Saccharomyces cerev...	16033255
C-8 sterol isomerase ERG2	Ki	=	13.0	nM	7.89	Affinity for ERG2 of Saccharomyces cerevisiae using [3H]ifenprodil or (+)-[3H]pe...	16033255

PubMed	DOI	Target Context	# Activities
16033255	10.1021/jm049073+	3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	1
16033255	10.1021/jm049073+	Sigma non-opioid intracellular receptor 1	1
16033255	10.1021/jm049073+	C-8 sterol isomerase ERG2	1

Data from ChEMBL 36 via Core Engine