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Compound Detail

CHEMBL361085

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Clc1ccccc1CNC[C@H]1CC[C@H](CCNc2ccccc2Cl)CC1

Basic Information

ChEMBL ID CHEMBL361085
Phase Preclinical
Structure Type MOL
InChI Key AINAOXBEBHZWSP-IYARVYRRSA-N
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

391.4
MW (Da)
6.39
ALogP
2
HBA
2
HBD
24.1
PSA (Ų)
0.54
QED
1
Ro5 Violations
8
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C22H28Cl2N2
MW 391.39
Aromatic Rings 2
Heavy Atoms 26
NP-Likeness -1.11

Activity Summary

Ki 3 meas. best 9.3

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Sigma non-opioid intracellular receptor 1
CHEMBL287
Ki 9.3 9.3 0.5 1
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase
CHEMBL4931
Ki 8.4 8.4 4.0 1
C-8 sterol isomerase ERG2
CHEMBL3224
Ki 7.19 7.19 65.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
16033255 10.1021/jm049073+ 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase 1
16033255 10.1021/jm049073+ Sigma non-opioid intracellular receptor 1 1
16033255 10.1021/jm049073+ C-8 sterol isomerase ERG2 1

Data from ChEMBL 36 via Core Engine