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Compound Detail

CHEMBL187615

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CC(C)[C@](C#N)(CCCN(C)CCc1ccccc1)c1ccccc1

Basic Information

ChEMBL ID CHEMBL187615
Phase Preclinical
Structure Type MOL
InChI Key DWAWDSVKAUWFHC-HSZRJFAPSA-N
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

334.5
MW (Da)
5.06
ALogP
2
HBA
0
HBD
27.0
PSA (Ų)
0.64
QED
1
Ro5 Violations
9
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

Natural Product First in Class Prodrug

Extended Properties

Molecular Formula C23H30N2
MW 334.51
Aromatic Rings 2
Heavy Atoms 25
NP-Likeness -0.26

Activity Summary

Ki 3 meas. best 9.0

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Sigma non-opioid intracellular receptor 1
CHEMBL287
Ki 9.0 9.0 1.0 1
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase
CHEMBL4931
Ki 8.22 8.22 6.0 1
C-8 sterol isomerase ERG2
CHEMBL3224
Ki 7.19 7.19 65.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
16033255 10.1021/jm049073+ 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase 1
16033255 10.1021/jm049073+ Sigma non-opioid intracellular receptor 1 1
16033255 10.1021/jm049073+ C-8 sterol isomerase ERG2 1

Data from ChEMBL 36 via Core Engine