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Compound Detail

CHEMBL2368401

(7S,8R)-6-ALLYLAMINO-7,8-DIMETHYL-8-PROPYL-5,6,7,8-TETRAHYDRO-NAPHTHALEN-2-OL
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C=CCN1CC[C@@]2(C)c3cc(O)ccc3CC1[C@H]2C

Basic Information

ChEMBL ID CHEMBL2368401
Name (7S,8R)-6-ALLYLAMINO-7,8-DIMETHYL-8-PROPYL-5,6,7,8-TETRAHYDRO-NAPHTHALEN-2-OL
Phase Preclinical
Structure Type MOL
InChI Key LGQCVMYAEFTEFN-SCWIMFDPSA-N
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

257.4
MW (Da)
3.10
ALogP
2
HBA
1
HBD
23.5
PSA (Ų)
0.82
QED
0
Ro5 Violations
2
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

Natural Product First in Class Prodrug

Extended Properties

Molecular Formula C17H23NO
MW 257.38
Aromatic Rings 1
Heavy Atoms 19
NP-Likeness 1.56

Activity Summary

Ki 3 meas. best 7.4

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Sigma non-opioid intracellular receptor 1
CHEMBL287
Ki 7.4 7.4 40.0 1
C-8 sterol isomerase ERG2
CHEMBL3224
Ki 5.33 5.33 4700.0 1
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase
CHEMBL4931
Ki 5.03 5.03 9300.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
16033255 10.1021/jm049073+ 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase 1
16033255 10.1021/jm049073+ Sigma non-opioid intracellular receptor 1 1
16033255 10.1021/jm049073+ C-8 sterol isomerase ERG2 1

Data from ChEMBL 36 via Core Engine