Compound Detail
CHEMBL36774
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL36774 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | JVBGBRBEKHETSN-DOFZRALJSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
9
Publications
0
Known Names
Molecular Properties
400.6
MW (Da)
7.94
ALogP
3
HBA
0
HBD
26.3
PSA (Ų)
0.16
QED
1
Ro5 Violations
16
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 4.92
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Fatty-acid amide hydrolase 1 CHEMBL3229 | IC50 | 4.92 | 4.92 | 12000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Fatty-acid amide hydrolase 1 | IC50 | = | 12000.0 | nM | 4.92 | Inhibition of fatty acid amide hydrolase (FAAH) was determined using rat brain h... | 12672252 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 12672252 | 10.1021/jm0210818 | Homo sapiens | 2 |
| 12672252 | 10.1021/jm0210818 | Fatty-acid amide hydrolase 1 | 2 |
| 12672252 | 10.1021/jm0210818 | Cannabinoid receptor 1 | 1 |
| 12672252 | 10.1021/jm0210818 | Cannabinoid receptor 2 | 1 |
| 12672252 | 10.1021/jm0210818 | Transient receptor potential cation channel subfamily V member 1 | 1 |
| 11741470 | 10.1021/jm015545y | U-937 | 1 |
| 11741470 | 10.1021/jm015545y | Cannabinoid receptor 1 | 1 |
| 11741470 | 10.1021/jm015545y | Cannabinoid receptor 2 | 1 |
| 11741470 | 10.1021/jm015545y | Transient receptor potential cation channel subfamily V member 1 | 1 |
Data from ChEMBL 36 via Core Engine