Assay Detail
Binding
CHEMBL680041
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Inhibition of fatty acid amide hydrolase (FAAH) was determined using rat brain homogenates as the enzyme source and [3H]anandamide as substrate
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Design, synthesis, and biological evaluation of new inhibitors of the endocannabinoid uptake: comparison with effects on fatty acid amidohydrolase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 4.61 | 5.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL39878 | — | — | 1 | 5.43 |
| CHEMBL36774 | — | — | 1 | 4.92 |
| CHEMBL37297 | — | — | 1 | 4.92 |
| CHEMBL37089 | — | — | 1 | 4.82 |
| CHEMBL36708 | — | — | 1 | 4.62 |
| CHEMBL288003 | — | — | 1 | 4.55 |
| CHEMBL39409 | — | — | 1 | 4.54 |
| CHEMBL434778 | — | — | 1 | 4.52 |
| CHEMBL39460 | — | — | 1 | 4.47 |
| CHEMBL286465 | — | — | 1 | 4.44 |
| CHEMBL287130 | — | — | 1 | 4.36 |
| CHEMBL38293 | — | — | 1 | 4.28 |
| CHEMBL284300 | — | — | 1 | 4.08 |
| CHEMBL1907956 | — | — | 1 | - |
| CHEMBL39399 | — | — | 1 | - |
| CHEMBL2093099 | — | — | 1 | - |
| CHEMBL40065 | — | — | 1 | - |
| CHEMBL287364 | — | — | 1 | - |
| CHEMBL291021 | — | — | 1 | - |
| CHEMBL285061 | — | — | 1 | - |
| CHEMBL431128 | — | — | 1 | - |
| CHEMBL38282 | — | — | 1 | - |
| CHEMBL41226 | — | — | 1 | - |
| CHEMBL290716 | — | — | 1 | - |
| CHEMBL287788 | — | — | 1 | - |
| CHEMBL39351 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL39878 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL36774 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL37297 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL37089 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL36708 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL288003 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL39409 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL434778 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL39460 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL286465 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL287130 | — | IC50 | = | 44000.0 | nM | 4.36 |
| CHEMBL38293 | — | IC50 | = | 53000.0 | nM | 4.28 |
| CHEMBL284300 | — | IC50 | = | 84000.0 | nM | 4.08 |
| CHEMBL1907956 | — | IC50 | > | 120000.0 | nM | - |
| CHEMBL39399 | — | IC50 | > | 120000.0 | nM | - |
| CHEMBL2093099 | — | IC50 | > | 120000.0 | nM | - |
| CHEMBL40065 | — | IC50 | > | 120000.0 | nM | - |
| CHEMBL287364 | — | IC50 | > | 120000.0 | nM | - |
| CHEMBL291021 | — | IC50 | - | — | - | |
| CHEMBL285061 | — | IC50 | = | 102000.0 | nM | - |
| CHEMBL431128 | — | IC50 | = | 112000.0 | nM | - |
| CHEMBL38282 | — | IC50 | > | 120000.0 | nM | - |
| CHEMBL41226 | — | IC50 | > | 120000.0 | nM | - |
| CHEMBL290716 | — | IC50 | = | 103000.0 | nM | - |
| CHEMBL287788 | — | IC50 | = | 113000.0 | nM | - |
| CHEMBL39351 | — | IC50 | > | 120000.0 | nM | - |