Compound Detail
CHEMBL3686884
E-7090 🧪 Phase II
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🧪 Phase II
CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(C5CCN(CCO)CC5)cc4)c3)c(OCCOC)cc21
Basic Information
| ChEMBL ID | CHEMBL3686884 |
| Name | E-7090 |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | IBHOLSBDZMIPPT-UHFFFAOYSA-N |
5
Targets
8
Activities
1
Assay Types
0
PK Parameters
0
Publications
4
Known Names
4
Indications
3
Mechanisms
Molecular Properties
587.7
MW (Da)
4.47
ALogP
9
HBA
3
HBD
127.2
PSA (Ų)
0.22
QED
1
Ro5 Violations
11
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Achiral |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Fibroblast growth factor receptor 1 inhibitor | INHIBITOR | Fibroblast growth factor receptor 1 | ✓ | ✓ |
| Fibroblast growth factor receptor 2 inhibitor | INHIBITOR | Fibroblast growth factor receptor 2 | ✓ | ✓ |
| Fibroblast growth factor receptor 3 inhibitor | INHIBITOR | Fibroblast growth factor receptor 3 | ✓ | ✓ |
Indications
Cholangiocarcinoma Neoplasms Breast Neoplasms Liver Diseases
Activity Summary
IC50 8 meas. best 8.35
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Fibroblast growth factor 2 CHEMBL3107 | IC50 | 8.35 | 8.35 | 4.5 | 1 |
| Fibroblast growth factor receptor 2 CHEMBL4142 | IC50 | 8.29 | 8.29 | 5.1 | 1 |
| Fibroblast growth factor receptor 3 CHEMBL2742 | IC50 | 8.27 | 8.245 | 5.4 | 2 |
| Fibroblast growth factor receptor 1 CHEMBL3650 | IC50 | 8.24 | 8.24 | 5.7 | 2 |
| Fibroblast growth factor receptor 4 CHEMBL3973 | IC50 | 6.19 | 6.18 | 644.5 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
Data from ChEMBL 36 via Core Engine