Compound Detail
CHEMBL3700336
LML-134 🧪 Phase II
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🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL3700336 |
| Name | LML-134 |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | BVUJMFFRMZRNAT-UHFFFAOYSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
1
Publications
2
Known Names
1
Indications
Molecular Properties
375.5
MW (Da)
1.06
ALogP
7
HBA
0
HBD
70.9
PSA (Ų)
0.79
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Achiral |
Indications
Sleep Disorders, Circadian Rhythm
Activity Summary
Ki 3 meas. best 8.96
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Histamine H3 receptor CHEMBL264 | Ki | 8.96 | 8.28 | 1.1 | 2 |
| Histamine H3 receptor CHEMBL5076 | Ki | 7.92 | 7.92 | 12.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Histamine H3 receptor | Ki | = | 1.1 | nM | 8.96 | LANCE Ultra cAMP Assay: The potency of compounds of the invention as H3 receptor... | - |
| Histamine H3 receptor | Ki | = | 12.0 | nM | 7.92 | Inhibition of Guinea Pig Ileum H3R | 31404862 |
| Histamine H3 receptor | Ki | = | 25.0 | nM | 7.6 | Radioligand Binding Assay: The affinity of compounds of the invention to the H3 ... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 31404862 | 10.1016/j.ejmech.2019.111569 | Histamine H3 receptor | 1 |
Data from ChEMBL 36 via Core Engine