Compound Detail
CHEMBL3701266
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Basic Information
| ChEMBL ID | CHEMBL3701266 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | CXJITJGGCTWHEG-UHFFFAOYSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
405.5
MW (Da)
0.99
ALogP
7
HBA
1
HBD
92.8
PSA (Ų)
0.60
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 10.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Fibroblast growth factor receptor 3 CHEMBL2742 | IC50 | 10.0 | 10.0 | 0.1 | 1 |
| Fibroblast growth factor receptor 1 CHEMBL3650 | IC50 | 8.92 | 8.92 | 1.2 | 1 |
| Fibroblast growth factor receptor 4 CHEMBL3973 | IC50 | 8.77 | 8.77 | 1.7 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Fibroblast growth factor receptor 3 | IC50 | = | 0.1 | nM | 10.0 | Inhibition Assay: Purified recombinant human FGFR3 protein was purchased from Ca... | - |
| Fibroblast growth factor receptor 1 | IC50 | = | 1.2 | nM | 8.92 | Inhibition Assay: Purified recombinant human FGFR4 protein was purchased from Ca... | - |
| Fibroblast growth factor receptor 4 | IC50 | = | 1.7 | nM | 8.77 | Inhibition Assay: Purified recombinant human FGFR4 protein was purchased from Ca... | - |
Data from ChEMBL 36 via Core Engine