Compound Detail
CHEMBL3716904
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COc1cc(OCc2csc(C3(O)CCC4(CC3)OCCO4)n2)c2cc(-c3cn4nc(OC)sc4n3)oc2c1
Basic Information
| ChEMBL ID | CHEMBL3716904 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SMSISCIMPYBOQW-UHFFFAOYSA-N |
2
Targets
7
Activities
2
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
570.6
MW (Da)
4.76
ALogP
13
HBA
1
HBD
122.6
PSA (Ų)
0.29
QED
2
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 5 meas. best 9.48
IC50 2 meas. best 8.72
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Proteinase-activated receptor 4 CHEMBL4691 | EC50 | 9.48 | 9.192 | 0.3 | 5 |
| Prothrombin CHEMBL204 | IC50 | 8.72 | 8.72 | 1.9 | 1 |
| Proteinase-activated receptor 4 CHEMBL4691 | IC50 | 8.72 | 8.72 | 1.9 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Proteinase-activated receptor 4 | EC50 | = | 0.33 | nM | 9.48 | Antagonist activity against human PAR4 expressed in HEK293 cells assessed as red... | - |
| Proteinase-activated receptor 4 | EC50 | = | 0.33 | nM | 9.48 | FLIPR Assay: Briefly, HEK293 EBNA PAR4 clone 20664.1J cells were plated 24 hrs. ... | - |
| Proteinase-activated receptor 4 | EC50 | = | 0.33 | nM | 9.48 | PAR4 FLIPR assay: The activity of the PAR4 antagonists of the present invention ... | - |
| Proteinase-activated receptor 4 | EC50 | = | 1.6 | nM | 8.8 | FLIPR Assay: Briefly, HEK293 EBNA PAR4 clone 20664.1J cells were plated 24 hrs. ... | - |
| Proteinase-activated receptor 4 | EC50 | = | 1.9 | nM | 8.72 | PRP Assay: Briefly, PRP or washed platelet suspension (100 μl) was pre-incubated... | - |
| Proteinase-activated receptor 4 | IC50 | = | 1.9 | nM | 8.72 | Antagonist activity against PAR4 in human platelet rich plasma assessed as inhib... | - |
| Prothrombin | IC50 | = | 1.9 | nM | 8.72 | Platelet Aggregation (PRP) Assay : The ability of the compounds of the current i... | - |
Data from ChEMBL 36 via Core Engine