Compound Detail
CHEMBL3717597
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COc1cc(OCc2cccc(-c3cnc(OC)nc3)c2)c2cc(-c3cn4nc(OC)sc4n3)oc2c1
Basic Information
| ChEMBL ID | CHEMBL3717597 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | HCSXISDLOQNVNM-UHFFFAOYSA-N |
2
Targets
4
Activities
1
Assay Types
4
PK Parameters
4
Publications
0
Known Names
Molecular Properties
515.5
MW (Da)
5.27
ALogP
11
HBA
0
HBD
106.0
PSA (Ų)
0.27
QED
3
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 9.16
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Proteinase-activated receptor 4 CHEMBL4691 | IC50 | 9.16 | 9.1567 | 0.7 | 3 |
| Plasma CHEMBL613424 | IC50 | 7.92 | 7.92 | 12.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| AUC | 1031.1 | ng.hr.mL-1 | Rattus norvegicus |
| T1/2 | 0.6 | hr | Homo sapiens |
| T1/2 | 1.033 | hr | Rattus norvegicus |
| T1/2 | 40.0 | hr | Rattus norvegicus |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Proteinase-activated receptor 4 | IC50 | = | 0.69 | nM | 9.16 | Antagonist activity against human PAR4 expressed in HEK293 cells assessed as red... | - |
| Proteinase-activated receptor 4 | IC50 | = | 0.69 | nM | 9.16 | FLIPR Assay: The activity of the PAR4 antagonists of the present invention were ... | - |
| Proteinase-activated receptor 4 | IC50 | = | 0.7 | nM | 9.15 | Antagonist activity at full length human PAR4 expressed in HEK293 cells assessed... | 35729784 |
| Plasma | IC50 | = | 12.0 | nM | 7.92 | Antiplatelet activity in human platelet-rich plasma assessed as inhibition of ga... | 35729784 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 35729784 | 10.1021/acs.jmedchem.2c00359 | ADMET | 5 |
| 35729784 | 10.1021/acs.jmedchem.2c00359 | Proteinase-activated receptor 4 | 1 |
| 35729784 | 10.1021/acs.jmedchem.2c00359 | Plasma | 1 |
| 35729784 | 10.1021/acs.jmedchem.2c00359 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine