Assay Detail
Functional
CHEMBL5148581
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiplatelet activity in human platelet-rich plasma assessed as inhibition of gamma thrombin induced platelet aggregation preincubated for 5 mins followed by gamma thrombin addition and measured upto 15 mins by plate reader assay
53
Total Activities
53
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Tissue | Plasma |
| Cell Type | Platelet |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Two Novel Antiplatelet Clinical Candidates (BMS-986120 and BMS-986141) That Antagonize Protease-Activated Receptor 4.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 53 | 7.63 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5173906 | — | — | 1 | 9.10 |
| CHEMBL3715264 | — | — | 1 | 8.96 |
| CHEMBL3717580 | — | — | 1 | 8.82 |
| CHEMBL3715516 | — | — | 1 | 8.80 |
| CHEMBL3718360 | — | — | 1 | 8.72 |
| CHEMBL3716552 | BMS-986141 | 2.0 | 1 | 8.68 |
| CHEMBL5194507 | — | — | 1 | 8.55 |
| CHEMBL3718564 | — | — | 1 | 8.54 |
| CHEMBL3716064 | — | — | 1 | 8.52 |
| CHEMBL3717275 | — | — | 1 | 8.44 |
| CHEMBL3719133 | — | — | 1 | 8.41 |
| CHEMBL5193311 | — | — | 1 | 8.40 |
| CHEMBL3715840 | — | — | 1 | 8.36 |
| CHEMBL3715848 | — | — | 1 | 8.33 |
| CHEMBL3717195 | — | — | 1 | 8.24 |
| CHEMBL3716066 | — | — | 1 | 8.17 |
| CHEMBL3716726 | — | — | 1 | 8.12 |
| CHEMBL3719069 | — | — | 1 | 8.08 |
| CHEMBL3717535 | — | — | 1 | 8.04 |
| CHEMBL3719106 | — | — | 1 | 8.01 |
| CHEMBL3718231 | — | — | 1 | 8.01 |
| CHEMBL3716636 | — | — | 1 | 8.00 |
| CHEMBL3715632 | — | — | 1 | 7.96 |
| CHEMBL3719264 | — | — | 1 | 7.92 |
| CHEMBL3717597 | — | — | 1 | 7.92 |
| CHEMBL3717937 | — | — | 1 | 7.92 |
| CHEMBL3719215 | — | — | 1 | 7.80 |
| CHEMBL3717235 | — | — | 1 | 7.75 |
| CHEMBL3717040 | — | — | 1 | 7.75 |
| CHEMBL3716230 | — | — | 1 | 7.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5173906 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL3715264 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL3717580 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL3715516 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL3718360 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL3716552 | BMS-986141 | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL5194507 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL3718564 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL3716064 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3717275 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL3719133 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL5193311 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3715840 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL3715848 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL3717195 | — | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL3716066 | — | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL3716726 | — | IC50 | = | 7.6 | nM | 8.12 |
| CHEMBL3719069 | — | IC50 | = | 8.4 | nM | 8.08 |
| CHEMBL3717535 | — | IC50 | = | 9.2 | nM | 8.04 |
| CHEMBL3719106 | — | IC50 | = | 9.8 | nM | 8.01 |
| CHEMBL3718231 | — | IC50 | = | 9.7 | nM | 8.01 |
| CHEMBL3716636 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3715632 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL3717937 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL3719264 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL3717597 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL3719215 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL3717235 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL3717040 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL3716230 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL3714821 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL5177223 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL3728620 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL3718639 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL3715722 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL3715093 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL3719331 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL5189522 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL3718059 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL5206095 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL3716950 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL3718313 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL5184586 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL3718606 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL3715852 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL3718163 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL5206065 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL3715642 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL5205126 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL3732490 | — | IC50 | = | 1600.0 | nM | 5.80 |