Compound Detail
CHEMBL3719331
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Basic Information
| ChEMBL ID | CHEMBL3719331 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | XTFJJLKNNRUJJV-UHFFFAOYSA-N |
2
Targets
4
Activities
1
Assay Types
4
PK Parameters
4
Publications
0
Known Names
Molecular Properties
485.5
MW (Da)
5.26
ALogP
10
HBA
0
HBD
96.8
PSA (Ų)
0.30
QED
1
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 8.97
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Proteinase-activated receptor 4 CHEMBL4691 | IC50 | 8.97 | 8.9667 | 1.1 | 3 |
| Plasma CHEMBL613424 | IC50 | 7.36 | 7.36 | 44.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| AUClast | - | - | Rattus norvegicus |
| T1/2 | 0.1167 | hr | Homo sapiens |
| T1/2 | 0.1167 | hr | Rattus norvegicus |
| t1/2 | - | - | Rattus norvegicus |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Proteinase-activated receptor 4 | IC50 | = | 1.06 | nM | 8.97 | Antagonist activity against human PAR4 expressed in HEK293 cells assessed as red... | - |
| Proteinase-activated receptor 4 | IC50 | = | 1.06 | nM | 8.97 | FLIPR Assay: The activity of the PAR4 antagonists of the present invention were ... | - |
| Proteinase-activated receptor 4 | IC50 | = | 1.1 | nM | 8.96 | Antagonist activity at full length human PAR4 expressed in HEK293 cells assessed... | 35729784 |
| Plasma | IC50 | = | 44.0 | nM | 7.36 | Antiplatelet activity in human platelet-rich plasma assessed as inhibition of ga... | 35729784 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 35729784 | 10.1021/acs.jmedchem.2c00359 | ADMET | 5 |
| 35729784 | 10.1021/acs.jmedchem.2c00359 | Proteinase-activated receptor 4 | 1 |
| 35729784 | 10.1021/acs.jmedchem.2c00359 | Plasma | 1 |
| 35729784 | 10.1021/acs.jmedchem.2c00359 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine