Compound Detail
CHEMBL3718564
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COc1ccc(-c2cccc(COc3cc(OC)cc4oc(-c5cn6nc(OC)sc6n5)cc34)c2)nc1
Basic Information
| ChEMBL ID | CHEMBL3718564 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | PIRVYNOHTBFSEF-UHFFFAOYSA-N |
3
Targets
6
Activities
1
Assay Types
4
PK Parameters
4
Publications
0
Known Names
Molecular Properties
514.6
MW (Da)
5.87
ALogP
10
HBA
0
HBD
93.1
PSA (Ų)
0.25
QED
2
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 6 meas. best 9.33
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Proteinase-activated receptor 4 CHEMBL4691 | IC50 | 9.33 | 9.125 | 0.5 | 4 |
| Unchecked CHEMBL612545 | IC50 | 8.54 | 8.54 | 2.9 | 1 |
| Plasma CHEMBL613424 | IC50 | 8.54 | 8.54 | 2.9 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| AUC | 1698.05 | ng.hr.mL-1 | Rattus norvegicus |
| T1/2 | 0.7667 | hr | Homo sapiens |
| T1/2 | 0.3167 | hr | Rattus norvegicus |
| T1/2 | 110.0 | hr | Rattus norvegicus |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Proteinase-activated receptor 4 | IC50 | = | 0.47 | nM | 9.33 | Antagonist activity against human PAR4 expressed in HEK293 cells assessed as red... | - |
| Proteinase-activated receptor 4 | IC50 | = | 0.47 | nM | 9.33 | FLIPR Assay: The activity of the PAR4 antagonists of the present invention were ... | - |
| Proteinase-activated receptor 4 | IC50 | = | 0.5 | nM | 9.3 | Antagonist activity at full length human PAR4 expressed in HEK293 cells assessed... | 35729784 |
| Proteinase-activated receptor 4 | IC50 | = | 2.86 | nM | 8.54 | Antagonist activity against PAR4 in human platelet rich plasma assessed as inhib... | - |
| Plasma | IC50 | = | 2.9 | nM | 8.54 | Antiplatelet activity in human platelet-rich plasma assessed as inhibition of ga... | 35729784 |
| Unchecked | IC50 | = | 2.86 | nM | 8.54 | FLIPR Assay: The activity of the PAR4 antagonists of the present invention were ... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 35729784 | 10.1021/acs.jmedchem.2c00359 | ADMET | 5 |
| 35729784 | 10.1021/acs.jmedchem.2c00359 | Proteinase-activated receptor 4 | 1 |
| 35729784 | 10.1021/acs.jmedchem.2c00359 | Plasma | 1 |
| 35729784 | 10.1021/acs.jmedchem.2c00359 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine