Compound Detail
CHEMBL5205126
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COc1cc(OCc2csc(-c3ccc(C(=O)O)cc3)n2)c2cc(-c3cn4nc(OC)sc4n3)oc2c1
Basic Information
| ChEMBL ID | CHEMBL5205126 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NAQNNHOIJNFGLP-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
4
PK Parameters
4
Publications
0
Known Names
Molecular Properties
534.6
MW (Da)
5.62
ALogP
11
HBA
1
HBD
121.2
PSA (Ų)
0.27
QED
3
Ro5 Violations
8
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 8.96
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Proteinase-activated receptor 4 CHEMBL4691 | IC50 | 8.96 | 8.96 | 1.1 | 1 |
| Plasma CHEMBL613424 | IC50 | 5.89 | 5.89 | 1300.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| AUClast | - | - | Rattus norvegicus |
| T1/2 | 2.0 | hr | Homo sapiens |
| T1/2 | 2.0 | hr | Rattus norvegicus |
| t1/2 | - | - | Rattus norvegicus |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Proteinase-activated receptor 4 | IC50 | = | 1.1 | nM | 8.96 | Antagonist activity at full length human PAR4 expressed in HEK293 cells assessed... | 35729784 |
| Plasma | IC50 | = | 1300.0 | nM | 5.89 | Antiplatelet activity in human platelet-rich plasma assessed as inhibition of ga... | 35729784 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 35729784 | 10.1021/acs.jmedchem.2c00359 | ADMET | 5 |
| 35729784 | 10.1021/acs.jmedchem.2c00359 | Proteinase-activated receptor 4 | 1 |
| 35729784 | 10.1021/acs.jmedchem.2c00359 | Plasma | 1 |
| 35729784 | 10.1021/acs.jmedchem.2c00359 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine