Compound Detail
CHEMBL37346
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Basic Information
| ChEMBL ID | CHEMBL37346 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | HANOGSNEKFKCMV-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
299.2
MW (Da)
4.74
ALogP
2
HBA
1
HBD
24.9
PSA (Ų)
0.74
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 5.26
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Epidermal growth factor receptor CHEMBL203 | IC50 | 5.26 | 5.26 | 5500.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Epidermal growth factor receptor | IC50 | = | 5500.0 | nM | 5.26 | Inhibition of the phosphorylation of a random polyglutamic acid/tyrosine copolym... | 9154973 |
| Epidermal growth factor receptor | IC50 | = | 5500.0 | nM | 5.26 | Evaluation of inhibitory activity against phospholipase C-gamma1 phosphorylation... | 7658435 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 9154973 | 10.1021/jm960789h | Epidermal growth factor receptor | 1 |
| 7658435 | 10.1021/jm00018a008 | Epidermal growth factor receptor | 1 |
Data from ChEMBL 36 via Core Engine