Assay Detail
Binding
CHEMBL677389
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of the phosphorylation of a random polyglutamic acid/tyrosine copolymer by human epidermal growth factor receptor(EGFR) prepared from human A431 carcinoma cells
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | A-431 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Tyrosine kinase inhibitors. 11. Soluble analogues of pyrrolo- and pyrazoloquinazolines as epidermal growth factor receptor inhibitors: synthesis, biological evaluation, and modeling of the mode of binding.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 8.25 | 10.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL29197 | — | — | 1 | 10.60 |
| CHEMBL39320 | — | — | 1 | 9.43 |
| CHEMBL40734 | — | — | 1 | 9.36 |
| CHEMBL39337 | — | — | 1 | 9.36 |
| CHEMBL289213 | — | — | 1 | 9.14 |
| CHEMBL36727 | — | — | 1 | 9.10 |
| CHEMBL416611 | — | — | 1 | 8.80 |
| CHEMBL287007 | — | — | 1 | 8.59 |
| CHEMBL39715 | — | — | 1 | 8.47 |
| CHEMBL36164 | — | — | 1 | 8.46 |
| CHEMBL40130 | — | — | 1 | 8.43 |
| CHEMBL38199 | — | — | 1 | 8.43 |
| CHEMBL36967 | — | — | 1 | 8.32 |
| CHEMBL289162 | — | — | 1 | 8.29 |
| CHEMBL39811 | — | — | 1 | 8.12 |
| CHEMBL39355 | — | — | 1 | 8.06 |
| CHEMBL37543 | — | — | 1 | 7.92 |
| CHEMBL287289 | — | — | 1 | 7.68 |
| CHEMBL290096 | — | — | 1 | 7.57 |
| CHEMBL287832 | — | — | 1 | 7.40 |
| CHEMBL37373 | — | — | 1 | 7.39 |
| CHEMBL36819 | — | — | 1 | 7.28 |
| CHEMBL289959 | — | — | 1 | 6.46 |
| CHEMBL37346 | — | — | 1 | 5.26 |
| CHEMBL289787 | — | — | 1 | - |
| CHEMBL35820 | — | — | 1 | - |
| CHEMBL37099 | — | — | 1 | - |
| CHEMBL39563 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL29197 | — | IC50 | = | 0.025 | nM | 10.60 |
| CHEMBL39320 | — | IC50 | = | 0.37 | nM | 9.43 |
| CHEMBL40734 | — | IC50 | = | 0.44 | nM | 9.36 |
| CHEMBL39337 | — | IC50 | = | 0.44 | nM | 9.36 |
| CHEMBL289213 | — | IC50 | = | 0.72 | nM | 9.14 |
| CHEMBL36727 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL416611 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL287007 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL39715 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL36164 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL40130 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL38199 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL36967 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL289162 | — | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL39811 | — | IC50 | = | 7.5 | nM | 8.12 |
| CHEMBL39355 | — | IC50 | = | 8.8 | nM | 8.06 |
| CHEMBL37543 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL287289 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL290096 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL287832 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL37373 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL36819 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL289959 | — | IC50 | = | 346.0 | nM | 6.46 |
| CHEMBL37346 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL289787 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL35820 | — | IC50 | = | 0.006 | nM | - |
| CHEMBL37099 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL39563 | — | IC50 | > | 100000.0 | nM | - |